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Article

Foxp3 controls regulatory T-cell function by interacting with AML1/Runx1.

Nature - 5 Apr 2007

Ono Masahiro, Yaguchi Hiroko, Ohkura Naganari, Kitabayashi Issay, Nagamura Yuko, Nomura Takashi, Miyachi Yoshiki, Tsukada Toshihiko, Sakaguchi Shimon

Abstract excerpt

Naturally arising CD25+CD4+ regulatory T cells (T(R) cells) are engaged in the maintenance of immunological self-tolerance and immune homeostasis by suppressing aberrant or excessive immune responses, such as autoimmune disease and allergy. T(R) cells specifically express the transcription factor Foxp3, a key regulator of T(R)-cell development and function. Ectopic expression of Foxp3 in conventional T cells is...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17377532
DOI: 10.1038/nature05673

Genes

TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Foxp3 controls regulatory T-cell function by interacting with AML1/Runx1.PMID 17377532Read ↗

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Transcription factors RUNX1 and RUNX3 in the induction and suppressive function of Foxp3+ inducible regulatory T cellsSemantic proximity Read ↗

Transcriptional control of regulatory T-cell differentiation.Semantic proximity Read ↗

Foxp3: a genetic foundation for regulatory T cell differentiation and function.Semantic proximity Read ↗

Foxo proteins cooperatively control the differentiation of Foxp3+ regulatory T cells.Semantic proximity Read ↗

Molecular and biological role of the FOXP3 N-terminal domain in immune regulation by T regulatory/suppressor cells.Semantic proximity Read ↗

Regulatory T cells and Foxp3.Semantic proximity Read ↗

Human T regulatory cells: on the way to cognition.Semantic proximity Read ↗

FOXP3 modifies the phenotypic and functional properties of regulatory T cells.Semantic proximity Read ↗

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