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Mutations in the mitochondrial DNA D-loop region are frequent in cervical cancer.

1 Jan 2005

Abstract excerpt

BACKGROUND: Mitochondrial DNA (mtDNA) is known for high mutation rates caused by lack of protective histones, inefficient DNA repair systems, and continuous exposure to mutagenic effects of oxygen radicals. Alterations in the non-coding displacement (D) loop of mitochondrial DNA are present in many cancers. It has been suggested that the extent of mitochondrial DNA mutations might be useful in the prognosis of...

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PMID: 16359547
DOI: 10.1186/1475-2867-5-34

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