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Article

Procollagen C proteinase enhancer 1 genes are important determinants of the mechanical properties and geometry of bone and the ultrastructure of connective tissues.

Molecular and cellular biology - 1 Jan 2006

Steiglitz Barry M, Kreider Jaclynn M, Frankenburg Elizabeth P, Pappano William N, Hoffman Guy G, Meganck Jeffrey A, Liang Xiaowen, Höök Magnus, Birk David E, Goldstein Steven A, Greenspan Daniel S

Abstract excerpt

Procollagen C proteinases (pCPs) cleave type I to III procollagen C propeptides as a necessary step in assembling the major fibrous components of vertebrate extracellular matrix. The protein PCOLCE1 (procollagen C proteinase enhancer 1) is not a proteinase but can enhance the activity of pCPs approximately 10-fold in vitro and has reported roles in inhibiting other proteinases and in growth control. Here we have...

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Identifiers

PMID: 16354695
DOI: 10.1128/MCB.26.1.238-249.2006
PMCID: PMC1317636

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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