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Article

Deletion of Mecom in mouse results in early-onset spinal deformity and osteopenia.

Bone - 1 Mar 2014

Juneja Subhash C, Vonica Alin, Zeiss Caroline, Lezon-Geyda Kimberly, Yatsula Bogdan, Sell David R, Monnier Vincent M, Lin Sharon, Ardito Thomas, Eyre David, Reynolds David, Yao Zhenqiang, Awad Hani A, Yu Hongbo, Wilson Michael, Honnons Sylvie, Boyce Brendan F, Xing Lianping, Zhang Yi, Perkins Archibald S

Abstract excerpt

Recent studies have indicated a role for a MECOM allele in susceptibility to osteoporotic fractures in humans. We have generated a mutation in Mecom in mouse (termed ME(m1)) via lacZ knock-in into the upstream transcription start site for the gene, resulting in disruption of Mds1 and Mds1-Evi1 tr...

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Source

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Identifiers

PMID: 24316420
DOI: 10.1016/j.bone.2013.11.020
PMCID: PMC4440591

Genes

IVD
MECOM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24316420-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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