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Article

SPARC and the N-propeptide of collagen I influence fibroblast proliferation and collagen assembly in the periodontal ligament.

PloS one - 1 Jan 2017

Rosset Emilie Moore, Trombetta-eSilva Jessica, Hepfer Glenn, Yao Hai, Bradshaw Amy Dodd

Abstract excerpt

The periodontal ligament (PDL) is a fibrous connective tissue that anchors tooth cementum into alveolar bone. Secreted protein acidic and rich in cysteine (SPARC) is a collagen-binding matricellular protein known to influence collagen fiber assembly in the PDL. In contrast, functional properties of the N-propeptide of collagen I, encoded in exon 2 of the COL1A1 gene, are poorly understood. In this study, the PDL...

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Source

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Identifiers

PMID: 28245286
DOI: 10.1371/journal.pone.0173209
PMCID: PMC5330531

Genes

SPARC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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