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Article

Deficiency of Procollagen C-Proteinase Enhancer 1 in Mice has No Major Impact on Cardiac Collagen and Function Under Basal Conditions.

Journal of cardiovascular pharmacology - 1 Nov 2021

Sansilvestri-Morel Patricia, Harouki-Crochemore Najah, Bertin Florence, Bertheux Hélène, Vermeil de Conchard Guy, Diguet Nicolas, Desfosses Emilie, Lecomte Mathilde, Gonzalez Arantxa, Diez Javier, Tupinon-Mathieu Isabelle, Delerive Philippe

Abstract excerpt

ABSTRACT: Maturation of fibrillar collagen is known to play a crucial role in the pathophysiology of myocardial fibrosis. Procollagen C-proteinase enhancer 1 (PCPE1) has a key role in procollagen maturation and collagen fibril formation. The phenotype of both male and female PCPE1 knock-out mice was investigated under basal conditions to explore the potential of PCPE1 as a therapeutic target in heart failure....

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Identifiers

PMID: 34369899
DOI: 10.1097/FJC.0000000000001122

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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