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Article

Strong cooperativity and loose geometry between CUB domains are the basis for procollagen c-proteinase enhancer activity.

The Journal of biological chemistry - 27 Nov 2009

Kronenberg Daniel, Vadon-Le Goff Sandrine, Bourhis Jean-Marie, Font Bernard, Eichenberger Denise, Hulmes David J S, Moali Catherine

Abstract excerpt

Procollagen C-proteinase enhancers (PCPE-1 and -2) specifically activate bone morphogenetic protein-1 (BMP-1) and other members of the tolloid proteinase family during C-terminal processing of fibrillar collagen precursors. PCPEs consist of two CUB domains (CUB1 and CUB2) and one NTR domain separated by one short and one long linker. It was previously shown that PCPEs can strongly interact with procollagen...

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Identifiers

PMID: 19801683
DOI: 10.1074/jbc.M109.046128
PMCID: PMC2785188

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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