Article
Differential expression of platelet-derived growth factor receptors in human malignant glioma cell lines.
The Journal of biological chemistry - 5 Sept 1991
Nistér M, Claesson-Welsh L, Eriksson A, Heldin C H, Westermark B
Abstract excerpt
Glioma cells in culture express platelet-derived growth factor (PDGF) A- and B-chains and secrete PDGF-like activity that is mainly PDGF-AA. In this work, we show that the PDGF alpha- and beta-receptors are independently expressed in human malignant glioma cells. We also define three different receptor phenotypes that are related to the morphology of glioma cells: cells with only alpha-receptors, only...
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