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Article

Differential expression of platelet-derived growth factor receptors in human malignant glioma cell lines.

The Journal of biological chemistry - 5 Sept 1991

Nistér M, Claesson-Welsh L, Eriksson A, Heldin C H, Westermark B

Abstract excerpt

Glioma cells in culture express platelet-derived growth factor (PDGF) A- and B-chains and secrete PDGF-like activity that is mainly PDGF-AA. In this work, we show that the PDGF alpha- and beta-receptors are independently expressed in human malignant glioma cells. We also define three different receptor phenotypes that are related to the morphology of glioma cells: cells with only alpha-receptors, only...

Topics

DNA
Down-Regulation
Gene Expression Regulation
Glioma
Humans
Phenotype
Platelet-Derived Growth Factor
Precipitin Tests
RNA, Messenger
Receptors, Cell Surface
Receptors, Platelet-Derived Growth Factor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Tumor Cells, Cultured

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Identifiers

PMID: 1653246

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1653246-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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