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Article

Aminoglycosides decrease glutathione peroxidase-1 activity by interfering with selenocysteine incorporation.

The Journal of biological chemistry - 10 Feb 2006

Handy Diane E, Hang Gaozhen, Scolaro John, Metes Nicole, Razaq Nadia, Yang Yi, Loscalzo Joseph

Abstract excerpt

Cellular glutathione peroxidase is a key intracellular antioxidant enzyme that contains a selenocysteine residue at its active site. Selenium, a selenocysteine incorporation sequence in the 3'-untranslated region of the glutathione peroxidase mRNA, and other translational cofactors are necessary for "read-through" of a UGA stop codon that specifies selenocysteine incorporation. Aminoglycoside antibiotics...

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Identifiers

PMID: 16354666
DOI: 10.1074/jbc.M511295200
PMCID: PMC1472404

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Aminoglycosides decrease glutathione peroxidase-1 activity by interfering with selenocysteine incorporation.PMID 16354666Read ↗

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