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Can recombinant human glutathione peroxidase 1 with high activity be efficiently produced in Escherichia coli ?

Antioxidants & redox signaling - 20 Mar 2014

Guo Xiao, Song Jian, Yu Yang, Wei Jingyan

Abstract excerpt

Cellular glutathione peroxidase 1 (GPx1) is an important antioxidant selenoenzyme. Due to the presence of selenocysteine (Sec) encoded by UGA, normally recognized as a stop codon, the expression of mammalian GPx with traditional recombinant DNA technology is extremely difficult. In this study, a series of human GPx1 (hGPx1) mutants with significantly high catalytic activities were produced for the first time in...

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Identifiers

PMID: 24093966
DOI: 10.1089/ars.2013.5617

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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