Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Hepatitis C Virus Subgenomic Replicon Requires an Active NS3 RNA Helicase

13 Dec 2005

Abstract excerpt

Mutations were introduced into the NS3 helicase region of a hepatitis C virus (HCV) Con1 subgenomic replicon to ascertain the role of the helicase in viral replication. One new replicon lacked two-thirds of the NS3 helicase (Deltahel), and six others contained one of the following six amino acid substitutions in NS3: R393A, F438A, T450I, E493K, W501A, and W501F. It has been previously reported that purified...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Hepatitis B Virus Studies
Share to Hepatitis C virus research
Share to Liver Disease Diagnosis and Treatment

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 16352565
DOI: 10.1128/jvi.80.1.404-411.2006

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Hepatitis C Virus Subgenomic Replicon Requires an Active NS3 RNA HelicasePMID 16352565Read ↗

In vitro efficacy of approved and experimental antivirals against novel genotype 3 hepatitis C virus subgenomic replicons.Semantic proximity Read ↗

Mutations in NS5B polymerase of hepatitis C virus: impacts on in vitro enzymatic activity and viral RNA replication in the subgenomic replicon cell culture.Semantic proximity Read ↗

NS3 from Hepatitis C Virus Strain JFH-1 Is an Unusually Robust Helicase That Is Primed To Bind and Unwind Viral RNA.Semantic proximity Read ↗

Structural and biological identification of residues on the surface of NS3 helicase required for optimal replication of the hepatitis C virus.Semantic proximity Read ↗

Replication of hepatitis C virus genotype 3a in cultured cells.Semantic proximity Read ↗

Replication studies using genotype 1a subgenomic hepatitis C virus replicons.Semantic proximity Read ↗

Production of infectious genotype 1b virus particles in cell culture and impairment by replication enhancing mutations.Semantic proximity Read ↗

Analysis of the Enzymatic Activity of an NS3 Helicase Genotype 3a Variant Sequence Obtained from a Relapse Patient.Semantic proximity Read ↗

Subgenomic replicon derived from a cell line infected with the hepatitis C virus.Semantic proximity Read ↗

Hepatitis C Virus Subgenomic Replicons in the Human Embryonic Kidney 293 Cell LineSemantic proximity Read ↗

Effect of Alpha Interferon on the Hepatitis C Virus RepliconSemantic proximity Read ↗

Hepatitis C virus replicons escape RNA interference induced by a short interfering RNA directed against the NS5b coding region.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.