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Article

Analysis of the Enzymatic Activity of an NS3 Helicase Genotype 3a Variant Sequence Obtained from a Relapse Patient.

PloS one - 1 Jan 2015

Provazzi Paola J S, Mukherjee Sourav, Hanson Alicia M, Nogueira Mauricio L, Carneiro Bruno M, Frick David N, Rahal Paula

Abstract excerpt

The hepatitis C virus (HCV) is a species of diverse genotypes that infect over 170 million people worldwide, causing chronic inflammation, cirrhosis and hepatocellular carcinoma. HCV genotype 3a is common in Brazil, and it is associated with a relatively poor response to current direct-acting antiviral therapies. The HCV NS3 protein cleaves part of the HCV polyprotein, and cellular antiviral proteins. It is...

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Identifiers

PMID: 26658750
DOI: 10.1371/journal.pone.0144638
PMCID: PMC4684341

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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