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Article

Distinct function of conserved amino acids in the fingers of Saccharomyces cerevisiae DNA polymerase alpha.

The Journal of biological chemistry - 23 May 2003

Ogawa Masanori, Limsirichaikul Siripan, Niimi Atsuko, Iwai Shigenori, Yoshida Shonen, Suzuki Motoshi

Abstract excerpt

Structural differences between class A and B DNA polymerases suggest that the motif B region, a wall of the catalytic pocket, may have evolved differentially in the two polymerase families. This study examines the function of the motif B residues in Saccharomyces cerevisiae DNA polymerase alpha (pol alpha). Effects of the mutations were determined by biochemical analysis and genetic complementation of a yeast...

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PMID: 12637557
DOI: 10.1074/jbc.M208605200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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