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Article

Mutagenic mechanisms of cancer-associated DNA polymerase ϵ alleles.

Nucleic acids research - 19 Apr 2021

Herzog Mareike, Alonso-Perez Elisa, Salguero Israel, Warringer Jonas, Adams David J, Jackson Stephen P, Puddu Fabio

Abstract excerpt

A single amino acid residue change in the exonuclease domain of human DNA polymerase ϵ, P286R, is associated with the development of colorectal cancers, and has been shown to impart a mutator phenotype. The corresponding Pol ϵ allele in the yeast Saccharomyces cerevisiae (pol2-P301R), was found to drive greater mutagenesis than an entirely exonuclease-deficient Pol ϵ (pol2-4), an unexpected phenotype of...

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Identifiers

PMID: 33764464
DOI: 10.1093/nar/gkab160
PMCID: PMC8053093

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