Article

Mutagenic mechanisms of cancer-associated DNA polymerase ε alleles

2020-09-04

Abstract excerpt

<h4>ABSTRACT</h4> A single amino acid residue change in the exonuclease domain of human DNA polymerase ε, P286R, is associated with the development of colorectal cancers, and has been shown to impart a mutagenic phenotype. Perhaps unexpectedly, the corresponding Pol ε allele in the yeast Saccharomyces cerevisiae ( pol2-P301R ), was found to drive greater mutagenesis than exonuclease-deficient Pol ε ( pol2-4 ),...

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Literature Corpus work: 2af6c53d-fbab-5c69-bc41-a180aa06e7f2
DOI: 10.1101/2020.09.04.270124

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