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Article

Crystal structure of folliculin reveals a hidDENN function in genetically inherited renal cancer.

Open biology - 1 Aug 2012

Nookala Ravi K, Langemeyer Lars, Pacitto Angela, Ochoa-Montaño Bernardo, Donaldson Jane C, Blaszczyk Beata K, Chirgadze Dimitri Y, Barr Francis A, Bazan J Fernando, Blundell Tom L

Abstract excerpt

Mutations in the renal tumour suppressor protein, folliculin, lead to proliferative skin lesions, lung complications and renal cell carcinoma. Folliculin has been reported to interact with AMP-activated kinase, a key component of the mammalian target of rapamycin pathway. Most cancer-causing mutations lead to a carboxy-terminal truncation of folliculin, pointing to a functional importance of this domain in tumour...

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Share to Carcinoma, Renal Cell
Share to Crystallography, X-Ray

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Electrophoresis, Polyacrylamide Gel

Share to Guanine Nucleotide Exchange Factors

Share to Guanosine Diphosphate

Share to Guanosine Triphosphate

Share to Kidney Neoplasms

Share to Protein Structure, Secondary

Source

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Identifiers

PMID: 22977732
DOI: 10.1098/rsob.120071
PMCID: PMC3438538

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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