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Article

The human telomerase catalytic subunit hTERT: organization of the gene and characterization of the promoter

1 Jan 1999

Abstract excerpt

Telomerase, the enzyme that synthesizes telomeric DNA, is not expressed in most human somatic cells but is activated with in vitro immortalization and during tumorigenesis, and repressed by cell differentiation. Of the two components of the core enzyme, the catalytic protein hTERT is limiting for activity. To investigate mechanisms of hTERT gene regulation, we have cloned genomic sequences encompassing the...

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PMID: 9887342
DOI: 10.1093/hmg/8.1.137

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