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Article

Regulation of cellular immortalization and steady-state levels of the telomerase reverse transcriptase through its carboxy-terminal domain.

Molecular and cellular biology - 1 Mar 2006

Middleman Elaine J, Choi Jinkuk, Venteicher Andrew S, Cheung Peggie, Artandi Steven E

Abstract excerpt

Telomerase maintains cell viability and chromosomal stability through the addition of telomere repeats to chromosome ends. The reactivation of telomerase through the upregulation of TERT, the telomerase protein subunit, is an important step during cancer development, yet TERT protein function and regulation remain incompletely understood. Despite its close sequence similarity to human TERT (hTERT), we find that...

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Identifiers

PMID: 16507993
DOI: 10.1128/MCB.26.6.2146-2159.2006
PMCID: PMC1430280

Genes

TERT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Regulation of cellular immortalization and steady-state levels of the telomerase reverse transcriptase through its carboxy-terminal domain.PMID 16507993Read ↗

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