IL-10 c.-592C>A (rs1800872) polymorphism is associated with cervical cancer.

doi:10.1007/s00432-020-03256-0

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Article

IL-10 c.-592C>A (rs1800872) polymorphism is associated with cervical cancer.

Journal of cancer research and clinical oncology - 1 Aug 2020

Pereira Ana Paula Lombardi, Trugilo Kleber Paiva, Okuyama Nádia Calvo Martins, Sena Michelle Mota, Couto-Filho José D'Oliveira, Watanabe Maria Angelica Ehara, de Oliveira Karen Brajão

Abstract excerpt

PURPOSE: Interleukin-10 (IL-10) is an immunoregulatory cytokine and its cervical and serum concentrations have been associated with a poor prognosis of cervical cancer. The rs1800872 polymorphism (c.-592C>A) in the promotor region of the IL-10 gene affects the production and expression of IL-10 and thus is able to determine the immune response profile in the cervix. Therefore, the aim of this work is to state the...

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PMID: 32447484
DOI: 10.1007/s00432-020-03256-0

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