Article
Genetic polymorphisms of FAS and FASL (CD95/CD95L) genes in cervical carcinogenesis: An analysis of haplotype and gene-gene interaction.
Gynecologic oncology - 1 Oct 2005
Lai Hung-Cheng, Lin Wei-Yu, Lin Ya-Wen, Chang Cheng-Chang, Yu Mu-Hsien, Chen Chia-Chi, Chu Tang-Yuan
Abstract excerpt
OBJECTIVE: Whereas human papillomavirus (HPV) infection is necessary but not sufficient for cervical carcinogenesis, host genetic variations may confer individual susceptibility. Resistance to apoptosis is a hallmark of cancer in which FAS/FAS ligand signaling plays an important role. The present study examines the hypothesis that genetic polymorphisms in FAS and FAS ligand genes, alone or in combination, are...
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