Article
IL-10 gene polymorphism c.-592C>A increases HPV infection susceptibility and influences IL-10 levels in HPV infected women.
Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases - 1 Sept 2017
Berti Fernanda Costa Brandão, Pereira Ana Paula Lombardi, Trugilo Kleber Paiva, Cebinelli Guilherme Cesar Martelossi, Silva Lorena Flor da Rosa Santos, Lozovoy Marcell Alysson Batisti, Simão Andréa Name Colado, Watanabe Maria Angelica Ehara, de Oliveira Karen Brajão
Abstract excerpt
Interleukin-10 (IL-10) influences HPV infection and viral persistence, favoring cervical immunosuppression and cervical carcinogenesis. IL-10 levels may be influenced by HPV itself and by IL-10 polymorphisms, including rs1800872 (c.-592C>A). Therefore, we evaluated the influence of IL-10 c.-592C>A polymorphism in HPV infection and in IL-10 plasmatic/cervical levels in HPV infected and non-infected women. The...
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