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Article

Cell Cycle-regulated Trafficking of Human Telomerase to Telomeres

7 Dec 2005

Abstract excerpt

Telomerase synthesizes telomeres at the ends of human chromosomes during S phase. The results presented here suggest that telomerase activity may be regulated by intranuclear trafficking of the key components of the enzyme in human cells. We examined the subcellular localization of endogenous human telomerase RNA (hTR) and telomerase reverse transcriptase (hTERT) in HeLa cervical carcinoma cells. Throughout most...

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Identifiers

PMID: 16339074
DOI: 10.1091/mbc.e05-09-0903

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