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Dynamics of Human Telomerase Holoenzyme Assembly and Subunit Exchange across the Cell Cycle

14 Jul 2015

Abstract excerpt

Human telomerase acts on telomeres during the genome synthesis phase of the cell cycle, accompanied by its concentration in Cajal bodies and transient colocalization with telomeres. Whether the regulation of human telomerase holoenzyme assembly contributes to the cell cycle restriction of telomerase function is unknown. We investigated the steady-state levels, assembly, and exchange dynamics of human telomerase...

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PMID: 26170453
DOI: 10.1074/jbc.m115.659359

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