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Human cells lacking coilin and Cajal bodies are proficient in telomerase assembly, trafficking and telomere maintenance

3 Dec 2014

Abstract excerpt

The RNA component of human telomerase (hTR) localizes to Cajal bodies, and it has been proposed that Cajal bodies play a role in the assembly of telomerase holoenzyme and telomerase trafficking. Here, the role of Cajal bodies was examined in Human cells deficient of coilin (i.e. coilin-knockout (KO) cells), in which no Cajal bodies are detected. In coilin-KO cells, a normal level of telomerase activity is...

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Share to Nuclear Structure and Function
Share to RNA Interference and Gene Delivery
Share to Telomeres, Telomerase, and Senescence

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PMID: 25477378
DOI: 10.1093/nar/gku1277

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