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Human telomerase RNA accumulation in Cajal bodies facilitates telomerase recruitment to telomeres and telomere elongation.

Molecular cell - 21 Sept 2007

Cristofari Gaël, Adolf Emem, Reichenbach Patrick, Sikora Katarzyna, Terns Rebecca M, Terns Michael P, Lingner Joachim

Abstract excerpt

Telomerase is required for telomere maintenance and is responsible for the immortal phenotype of cancer cells. How telomerase is assembled and reaches telomeres in the context of nuclear architecture is not understood. Recently, the telomerase RNA subunit (hTR) was shown to accumulate in Cajal bodies (CBs), subnuclear structures implicated in ribonucleoprotein maturation. However, the functional relevance of this...

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Identifiers

PMID: 17889662
DOI: 10.1016/j.molcel.2007.07.020

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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