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Article

Human telomerase RNA and box H/ACA scaRNAs share a common Cajal body–specific localization signal

23 Feb 2004

Abstract excerpt

Telomerase is a ribonucleoprotein reverse transcriptase that uses its RNA component as a template for synthesis of telomeric DNA repeats at the ends of linear eukaryotic chromosomes. Here, fluorescence in situ hybridization demonstrates that in HeLa cancer cells, human telomerase RNA (hTR) accumulates in the nucleoplasmic Cajal bodies (CBs). Localization of transiently expressed hTR to CBs is supported by a short...

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PMID: 14981093
DOI: 10.1083/jcb.200310138

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