Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Beta-defensin genomic copy number is not a modifier locus for cystic fibrosis.

Journal of negative results in biomedicine - 7 Dec 2005

Hollox Edward J, Davies Jane, Griesenbach Uta, Burgess Juliana, Alton Eric W F W, Armour John A L

Abstract excerpt

Human beta-defensin 2 (DEFB4, also known as DEFB2 or hBD-2) is a salt-sensitive antimicrobial protein that is expressed in lung epithelia. Previous work has shown that it is encoded in a cluster of beta-defensin genes at 8p23.1, which varies in copy number between 2 and 12 in different individuals. We determined the copy number of this locus in 355 patients with cystic fibrosis (CF), and tested for correlation...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles
Share to beta-Defensins
Share to Cohort Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cystic Fibrosis

Share to Diploidy

Share to DNA Probes

Share to Gene Dosage

Share to Genome, Human

Source

Open in PubMed Open full text

Identifiers

PMID: 16336654
DOI: 10.1186/1477-5751-4-9
PMCID: PMC1318481

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Beta-defensin genomic copy number is not a modifier locus for cystic fibrosis.PMID 16336654Read ↗

Copy number variation of the beta-defensin genes in europeans: no supporting evidence for association with lung function, chronic obstructive pulmonary disease or asthma.Semantic proximity Read ↗

Genomic copy number determines functional expression of {beta}-defensin 2 in airway epithelial cells and associates with chronic obstructive pulmonary disease.Semantic proximity Read ↗

Both copy number and sequence variations affect expression of human DEFB4.Semantic proximity Read ↗

Copy number variation of beta-defensins and relevance to disease.Semantic proximity Read ↗

Analysis of beta-defensin and Toll-like receptor gene copy number variation in celiac disease.Semantic proximity Read ↗

A chromosome 8 gene-cluster polymorphism with low human beta-defensin 2 gene copy number predisposes to Crohn disease of the colon.Semantic proximity Read ↗

Extensive normal copy number variation of a beta-defensin antimicrobial-gene cluster.Semantic proximity Read ↗

High-resolution mapping of the 8p23.1 beta-defensin cluster reveals strictly concordant copy number variation of all genes.Semantic proximity Read ↗

Association of higher DEFB4 genomic copy number with Crohn's disease.Semantic proximity Read ↗

Copy Number Variation of the Beta Defensin Gene Cluster on Chromosome 8p Influences the Bacterial Microbiota within the Nasopharynx of Otitis-Prone ChildrenSemantic proximity Read ↗

Evidence for duplication of the human defensin gene DEFB4 in chromosomal region 8p22-23 and implications for the analysis of SNP allele distribution.Semantic proximity Read ↗

Low DEFB4 copy number and high systemic hBD-2 and IL-22 levels are associated with dermatophytosis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.