Article
Copy number variation of the beta-defensin genes in europeans: no supporting evidence for association with lung function, chronic obstructive pulmonary disease or asthma.
PloS one - 1 Jan 2014
Wain Louise V, Odenthal-Hesse Linda, Abujaber Razan, Sayers Ian, Beardsmore Caroline, Gaillard Erol A, Chappell Sally, Dogaru Cristian M, McKeever Tricia, Guetta-Baranes Tamar, Kalsheker Noor, Kuehni Claudia E, Hall Ian P, Tobin Martin D, Hollox Edward J
Abstract excerpt
Lung function measures are heritable, predict mortality and are relevant in diagnosis of chronic obstructive pulmonary disease (COPD). COPD and asthma are diseases of the airways with major public health impacts and each have a heritable component. Genome-wide association studies of SNPs have revealed novel genetic associations with both diseases but only account for a small proportion of the heritability....
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