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Article

A chromosome 8 gene-cluster polymorphism with low human beta-defensin 2 gene copy number predisposes to Crohn disease of the colon.

American journal of human genetics - 1 Sept 2006

Fellermann Klaus, Stange Daniel E, Schaeffeler Elke, Schmalzl Hartmut, Wehkamp Jan, Bevins Charles L, Reinisch Walter, Teml Alexander, Schwab Matthias, Lichter Peter, Radlwimmer Bernhard, Stange Eduard F

Abstract excerpt

Defensins are endogenous antimicrobial peptides that protect the intestinal mucosa against bacterial invasion. It has been suggested that deficient defensin expression may underlie the chronic inflammation of Crohn disease (CD). The DNA copy number of the beta-defensin gene cluster on chromosome...

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Identifiers

PMID: 16909382
DOI: 10.1086/505915
PMCID: PMC1559531

Genes

HBD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-16909382-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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A chromosome 8 gene-cluster polymorphism with low human beta-defensin 2 gene copy number predisposes to Crohn disease of the colon.PMID 16909382Read ↗

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