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Article

Copy Number Variation of the Beta Defensin Gene Cluster on Chromosome 8p Influences the Bacterial Microbiota within the Nasopharynx of Otitis-Prone Children

27 May 2014

Abstract excerpt

As there is increasing evidence that aberrant defensin expression is related to susceptibility for infectious disease and inflammatory disorders, we sought to determine if copy number of the beta-defensin gene cluster located on chromosome 8p23.1 (DEFB107, 106, 105, 104, 103, DEFB4 and SPAG11), that shows copy number variation as a block, was associated with susceptibility to otitis media (OM). The gene DEFB103...

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Antimicrobial Peptides and Activities
Ear Surgery and Otitis Media
Respiratory viral infections research

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 24867293
DOI: 10.1371/journal.pone.0098269

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Copy Number Variation of the Beta Defensin Gene Cluster on Chromosome 8p Influences the Bacterial Microbiota within the Nasopharynx of Otitis-Prone ChildrenPMID 24867293Read ↗

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