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Article

Extensive normal copy number variation of a beta-defensin antimicrobial-gene cluster.

American journal of human genetics - 1 Sept 2003

Hollox E J, Armour J A L, Barber J C K

Abstract excerpt

Using a combination of multiplex amplifiable probe hybridization and semiquantitative fluorescence in situ hybridization (SQ-FISH), we analyzed DNA copy number variation across chromosome band 8p23.1, a region that is frequently involved in chromosomal rearrangements. We show that a cluster of at least three antimicrobial beta-defensin genes (DEFB4, DEFB103, and DEFB104) at 8p23.1 are polymorphic in copy number,...

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Identifiers

PMID: 12916016
DOI: 10.1086/378157
PMCID: PMC1180683

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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