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Article

Analysis of beta-defensin and Toll-like receptor gene copy number variation in celiac disease.

Human immunology - 1 Aug 2010

Fernandez-Jimenez Nora, Castellanos-Rubio Ainara, Plaza-Izurieta Leticia, Gutierrez Galder, Castaño Luis, Vitoria Juan Carlos, Bilbao Jose Ramon

Abstract excerpt

Celiac disease (CD) is an immune-mediated disorder of the gut in which innate and adaptive responses are involved. Toll-like receptor (TLR) 2 and TLR4 participate in host defense through antigen recognition, and show altered expression in CD gut mucosa. beta-defensins are inducible antimicrobial peptides, and DEFB gene copy number polymorphisms have been associated with autoimmune and inflammatory disorders. We...

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Source

Identifiers

PMID: 20483368
DOI: 10.1016/j.humimm.2010.05.012

Genes

TLR4
TLR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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