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Article

Genomic copy number determines functional expression of {beta}-defensin 2 in airway epithelial cells and associates with chronic obstructive pulmonary disease.

American journal of respiratory and critical care medicine - 15 Jul 2010

Janssens Wim, Nuytten Hilde, Dupont Lieven J, Van Eldere Johan, Vermeire Severine, Lambrechts Diether, Nackaerts Kristiaan, Decramer Marc, Cassiman Jean-Jacques, Cuppens Harry

Abstract excerpt

RATIONALE: Copy number variations of the cluster of beta-defensin genes have been associated with psoriasis and inflammatory bowel disease. Controversy still exists on whether the beta-defensins genes determine susceptibility for chronic obstructive pulmonary disease (COPD). OBJECTIVES: We investigated whether genomic copy number variations of the beta-defensin gene cluster have a functional role in airway...

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Identifiers

PMID: 20378733
DOI: 10.1164/rccm.200905-0767OC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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