Article
Prognostic significance of the polymorphisms in thymidylate synthase and methylenetetrahydrofolate reductase gene in lung cancer.
Anticancer research - 1 Jan 2000
Takehara Akira, Kawakami Kazuyuki, Ohta Naohiro, Oyama Kaeko, Ota Yasuhiko, Oda Makoto, Watanabe Go
Abstract excerpt
BACKGROUND: Thymidylate synthase (TS) and methylenetetrahydrofolate reductase (MTHFR) play important roles in folate metabolism. Previous studies have suggested that TS expression is a prognostic factor in non-small cell lung cancer (NSCLC). The TS gene has a variable number of tandem repeats (VNTR) and single nucleotide polymorphism (SNP) in the 5'-untranslated region, which are associated with TS expression....
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