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Article

The Effectiveness of Pemetrexed Monotherapy Depending on Polymorphisms in TS and MTHFR Genes as Well as Clinical Factors in Advanced NSCLC Patients.

Pathology oncology research : POR - 1 Jan 2016

Kucharczyk Tomasz, Krawczyk Paweł, Powrózek Tomasz, Kowalski Dariusz M, Ramlau Rodryg, Kalinka-Warzocha Ewa, Knetki-Wróblewska Magdalena, Winiarczyk Kinga, Krzakowski Maciej, Milanowski Janusz

Abstract excerpt

In NSCLC, second-line chemotherapy using pemetrexed or docetaxel has limited efficacy and should be dedicated to selected groups of patients. Pemetrexed is an antifolate compound with the ability to inhibit enzymes (TS, DHFR and GARFT) involved in pyrimidine and purine synthesis. The objective of this study was to evaluate the association between polymorphisms of TS and MHFR genes and clinical outcomes in NSCLC...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Methylenetetrahydrofolate Reductase (NADPH2)

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Source

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Identifiers

PMID: 26277606
DOI: 10.1007/s12253-015-9966-z
PMCID: PMC4681747

Genes

MTHFR
DHFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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