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Article

Methylenetetrahydrofolate reductase C677T polymorphism in patients with lung cancer in a Korean population.

BMC medical genetics - 22 Feb 2011

Cui Lian-Hua, Shin Min-Ho, Kim Hee Nam, Song Hye-Rim, Piao Jin-Mei, Kweon Sun-Seog, Choi Jin-Su, Yun Woo-Jun, Kim Young-Chul, Oh In-Jae, Kim Kyu-Sik

Abstract excerpt

BACKGROUND: This study was designed to investigate an association between methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism and the risk of lung cancer in a Korean population. METHODS: We conducted a large-scale, case-control study involving 3938 patients with newly diagnosed lung cancer and 1700 healthy controls. Genotyping was performed with peripheral blood DNA for MTHFR C677T polymorphisms....

Topics

Adenocarcinoma
Aged
Alleles
Base Sequence
Carcinoma, Large Cell
Carcinoma, Squamous Cell
Case-Control Studies
Confidence Intervals
DNA Primers
DNA, Neoplasm

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Female

Gene Frequency

Genetic Predisposition to Disease

Humans

Lung Neoplasms

Male

Methylenetetrahydrofolate Reductase (NADPH2)

Middle Aged

Source

Open in PubMed Open full text

Identifiers

PMID: 21342495
DOI: 10.1186/1471-2350-12-28
PMCID: PMC3048494

Genes

MTHFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-21342495-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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