Article
Prognostic implications of thymidylate synthase gene polymorphisms in patients with advanced small bowel adenocarcinoma treated with first-line fluoropyrimidine-based chemotherapy.
Oncology reports - 1 Jul 2015
Yhim Ho-Young, Cho Sang-Hee, Kim Sam Yong, Cho In Sung, Lee Kyu Taek, Lee Won Sup, Lee Soon Il, Park Moo Rim, Park Sang-Gon, Han Hye-Suk, Choi Yoon Seok, Chung Ik-Joo, Shim Hyun-Jeong, Lee Na-Ri, Song Eun-Kee, Kim Hee Sun, Yim Chang-Yeol
Abstract excerpt
Thymidylate synthase (TS) gene polymorphisms such as tandem repeat (TR) polymorphisms and single-nucleotide polymorphisms (SNPs) affect transcriptional efficiency of the TS gene and may be prognostic markers for fluoropyrimidine-based therapy in various gastrointestinal cancers. However, data for...
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