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Article

The hOGG1 Ser326Cys gene polymorphism is associated with decreased insulin sensitivity in subjects with normal glucose tolerance.

Journal of human genetics - 1 Jan 2006

Wang Chiao-Ling, Hsieh Ming-Chia, Hsin Shih-Chieh, Lin Hsing-Yi, Lin Kun-Der, Lo Chao-Sheng, Chen Zhao-Hong, Shin Shyi-Jang

Abstract excerpt

Increased oxidative stress has been observed to contribute the development of insulin resistance. Oxidative stress is known to increase the conversion of deoxyguanosine (dG) to 8-hydroxy-2'-deoxyguanosine (8-OHdG). Human 8-oxoguanine glycosylase (hOGG1) is the key component responsible for the removal of 8-OHdG from oxidatively damaged DNA. The repair activity of the hOGG1 Ser326Cys gene variant has been...

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PMID: 16333523
DOI: 10.1007/s10038-005-0335-8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Click a neighbor to travelStep 1 · 12 closest

The hOGG1 Ser326Cys gene polymorphism is associated with decreased insulin sensitivity in subjects with normal glucose tolerance.PMID 16333523Read ↗

Associations between hOGG1 Ser326Cys polymorphism and increased body mass index and fasting glucose level in the Japanese general population.Semantic proximity Read ↗

Association of the Ser326Cys polymorphism in the OGG1 gene with type 2 DM.Semantic proximity Read ↗

Meta-analysis of the association between hOGG1 Ser326Cys polymorphism and risk of colorectal cancer based on case--control studies.Semantic proximity Read ↗

hOGG1 SER326CYS genetic polymorphism in a Turkish population.Semantic proximity Read ↗

hOGG1 Ser326Cys polymorphism modifies the significance of the environmental risk factor for colon cancer.Semantic proximity Read ↗

Association of OGG1 Ser326Cys polymorphism and pancreatic cancer susceptibility: evidence from a meta-analysis.Semantic proximity Read ↗

The hOGG1 Ser326Cys polymorphism contributes to digestive system cancer susceptibility: evidence from 48 case-control studies.Semantic proximity Read ↗

Correlating blood levels of 8-hydroxydeoxyguanosine to hOGG1 genotypes and the incidence of ischemic cardiomyopathy.Semantic proximity Read ↗

The 8-oxoguanine DNA N-glycosylase 1 (hOGG1) Ser326Cys variant affects the susceptibility to Graves' disease.Semantic proximity Read ↗

The Ser(326)Cys polymorphism of 8-oxoguanine glycosylase 1 (OGG1) is associated with type 2 diabetes in Mexican Americans.Semantic proximity Read ↗

Association of OGG1 Ser326Cys polymorphism with colorectal cancer risk: a meta-analysis.Semantic proximity Read ↗

Meta-analysis demonstrates lack of association of the hOGG1 Ser326Cys polymorphism with bladder cancer risk.Semantic proximity Read ↗

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