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Article

Associations between hOGG1 Ser326Cys polymorphism and increased body mass index and fasting glucose level in the Japanese general population.

Journal of epidemiology - 1 Jan 2014

Hara Megumi, Nakamura Kazuyo, Nanri Hinako, Nishida Yuichiro, Hishida Asahi, Kawai Sayo, Hamajima Nobuyuki, Kita Yoshikuni, Suzuki Sadao, Mantjoro Eva Mariane, Ohnaka Keizo, Uemura Hirokazu, Matsui Daisuke, Oze Isao, Mikami Haruo, Kubo Michiaki, Tanaka Hideo

Abstract excerpt

BACKGROUND: Evidence suggests that Ser326Cys, a genetic polymorphism of human 8-oxoguanine glycosylase 1 (hOGG1), is associated with insulin resistance and type 2 diabetes; however, the underlying mechanism is unclear. Recently, an animal study showed a significant association between the hOGG1 genotype and obesity, although evidence for such an association in humans is limited. The purpose of this study was to...

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Identifiers

PMID: 24998955
DOI: 10.2188/jea.je20140002
PMCID: PMC4150008

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Associations between hOGG1 Ser326Cys polymorphism and increased body mass index and fasting glucose level in the Japanese general population.PMID 24998955Read ↗

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