Article
Subcellular targeting of oxidants during endothelial cell migration.
The Journal of cell biology - 5 Dec 2005
Wu Ru Feng, Xu You Cheng, Ma Zhenyi, Nwariaku Fiemu E, Sarosi George A, Terada Lance S
Abstract excerpt
Endogenous oxidants participate in endothelial cell migration, suggesting that the enzymatic source of oxidants, like other proteins controlling cell migration, requires precise subcellular localization for spatial confinement of signaling effects. We found that the nicotinamide adenine dinucleotide phosphate reduced (NADPH) oxidase adaptor p47(phox) and its binding partner TRAF4 were sequestered within nascent,...
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