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Article

Spontaneous development of synovitis and cartilage degeneration in transgenic mice overexpressing cathepsin K.

Arthritis and rheumatism - 1 Dec 2005

Morko Jukka, Kiviranta Riku, Joronen Kirsi, Säämänen Anna-Marja, Vuorio Eero, Salminen-Mankonen Heli

Abstract excerpt

OBJECTIVE: Several recent studies have demonstrated that cathepsin K, a proteolytic enzyme capable of degrading native fibrillar collagen, is overexpressed in osteoarthritic cartilage and inflamed synovial tissue. However, it is not known whether increased cathepsin K production is a primary or a secondary event in these diseases. The availability of transgenic UTU17 mice, which exhibit constitutive...

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Source

Identifiers

PMID: 16329095
DOI: 10.1002/art.21423

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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