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Article

Thyroid functions of mouse cathepsins B, K, and L.

The Journal of clinical investigation - 1 Jun 2003

Friedrichs Bianca, Tepel Carmen, Reinheckel Thomas, Deussing Jan, von Figura Kurt, Herzog Volker, Peters Christoph, Saftig Paul, Brix Klaudia

Abstract excerpt

Thyroid function depends on processing of the prohormone thyroglobulin by sequential proteolytic events. From in vitro analysis it is known that cysteine proteinases mediate proteolytic processing of thyroglobulin. Here, we have analyzed mice with deficiencies in cathepsins B, K, L, B and K, or K and L in order to investigate which of the cysteine proteinases is most important for proteolytic processing of...

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Source

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Identifiers

PMID: 12782676
DOI: 10.1172/JCI15990
PMCID: PMC156100

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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