Article
Cathepsin K deficiency partially inhibits, but does not prevent, bone destruction in human tumor necrosis factor-transgenic mice.
Arthritis and rheumatism - 1 Feb 2008
Schurigt Uta, Hummel Klaus M, Petrow Peter K, Gajda Mieczyslaw, Stöckigt Renate, Middel Peter, Zwerina Jochen, Janik Tobias, Bernhardt Ricardo, Schüler Susann, Scharnweber Dieter, Beckmann Felix, Saftig Paul, Kollias George, Schett Georg, Wiederanders Bernd, Bräuer Rolf
Abstract excerpt
OBJECTIVE: Cathepsin K is believed to have an eminent role in the pathologic resorption of bone. However, several studies have shown that other proteinases also participate in this process. In order to clarify the contribution of cathepsin K to the destruction of arthritic bone, we applied the human tumor necrosis factor (hTNF)-transgenic mouse model, in which severe polyarthritis characterized by strong...
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