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Article

Genetic deficiency of Syk protects mice from autoantibody‐induced arthritis

3 Mar 2010

Abstract excerpt

OBJECTIVE: The Syk tyrosine kinase plays an important role in diverse functions in hematopoietic lineage cells. Although previous in vitro and pharmacologic analyses suggested Syk to be a possible player in the development of autoimmune arthritis, no in vivo genetic studies addressing that issue have yet been reported. The aim of the present study was to test whether genetic deficiency of Syk affects...

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PMID: 20201079
DOI: 10.1002/art.27438

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Genetic deficiency of Syk protects mice from autoantibody‐induced arthritisPMID 20201079Read ↗

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