Article
Transgenic mouse models for studying the role of cartilage macromolecules in osteoarthritis.
Rheumatology (Oxford, England) - 1 Aug 2002
Helminen H J, Säämänen A-M, Salminen H, Hyttinen M M
Abstract excerpt
The development of transgenic technology has made possible the generation of targeted gene-mutated mouse lines suitable for use in experimental osteoarthritis (OA) research. Transgenic mice harbouring mutations in cartilage collagen types II and IX develop early-onset OA and are therefore promising models of age-related OA, even though the mice often show signs of chondrodysplasia. Also, mouse lines harbouring...
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