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Plasma membrane Ca2+ ATPase isoform 1 down-regulated in human oral cancer

1 Jan 2006

Abstract excerpt

The plasma membrane Ca(2+) ATPase (PMCA) is an essential regulator of free intracellular calcium. Recent studies have reported aberrant expression of the PMCA1 gene, a member of the PMCA family, in several cancer cell types. To elucidate the contribution of PMCA1 to oral carcinogenesis, we analyzed genetic and epigenetic changes and mRNA and protein expression in primary oral squamous cell carcinomas (OSCCs),...

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PMID: 16328033
DOI: 10.3892/or.15.1.49

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