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Article

ATP2A3 gene is involved in cancer susceptibility.

Cancer genetics and cytogenetics - 15 Jan 2009

Korosec Branka, Glavac Damjan, Volavsek Metka, Ravnik-Glavac Metka

Abstract excerpt

The sarco/endoplasmatic reticulum calcium-ATPase (SERCA) translocates Ca(2+) from cytosol to the lumen of the ER and thus regulates Ca(2+) homeostasis, perturbations of which have been suggested to contribute to cancer. We have previously detected an increased number of alterations in the ATP2A2 gene in various cancer types and in the ATP2A3 gene in head and neck squamous cell carcinoma. Here, we further analyzed...

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Identifiers

PMID: 19100511
DOI: 10.1016/j.cancergencyto.2008.10.007

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