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Article

Polymorphisms in the glutathione S-transferase mu cluster are associated with tumour progression and patient outcome in colorectal cancer.

International journal of oncology - 1 Jan 2006

Holley Sarah L, Rajagopal Ramesh, Hoban Paul R, Deakin Mark, Fawole Adeshina S, Elder James B, Elder Jackie, Smith Victoria, Strange Richard C, Fryer Anthony A

Abstract excerpt

Glutathione S-transferase (GST) enzymes catalyse the detoxification of by-products of reactive oxygen species and are thus important in cellular defence mechanisms. The GSTs are polymorphic with allelic variants encoding isoforms with functional differences. GST polymorphism has been associated with susceptibility and clinical outcome in patients with cancer. In this retrospective cohort, we have investigated...

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Source

Identifiers

PMID: 16328000

Genes

GSTM3
GSTM1
GSTP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Polymorphisms in the glutathione S-transferase mu cluster are associated with tumour progression and patient outcome in colorectal cancer.PMID 16328000Read ↗

GSTM1 and GSTP1 Polymorphisms Affect Outcome in Colorectal Adenocarcinoma.Semantic proximity Read ↗

Genetic variants in GSTM3 gene within GSTM4-GSTM2-GSTM1-GSTM5-GSTM3 cluster influence breast cancer susceptibility depending on GSTM1.Semantic proximity Read ↗

Glutathione-S-transferase gene polymorphisms in colorectal cancer patients: interaction between GSTM1 and GSTM3 allele variants as a risk-modulating factor.Semantic proximity Read ↗

Glutathione S-transferase M1 null genotype related to poor prognosis of colorectal cancer.Semantic proximity Read ↗

Susceptibility genes: GSTM1 and GSTM3 as genetic risk factors in bladder cancer.Semantic proximity Read ↗

Glutathione S-transferase mu gene variants and colorectal cancer development--use of sequence-specific probes for an Iranian population.Semantic proximity Read ↗

Relationship between the GSTM1 genetic polymorphism and susceptibility to bladder, breast and colon cancer.Semantic proximity Read ↗

A T2517C polymorphism in the GSTM4 gene is associated with risk of developing lung cancer.Semantic proximity Read ↗

Glutathione S-transferase T1 polymorphisms are associated with outcome in colorectal cancer.Semantic proximity Read ↗

Genetic variation in the GSTM3 promoter confer risk and prognosis of renal cell carcinoma by reducing gene expression.Semantic proximity Read ↗

Genetic polymorphisms in GST genes and survival of colorectal cancer patients treated with chemotherapy.Semantic proximity Read ↗

Glutathione peroxidase tagSNPs: associations with rectal cancer but not with colon cancer.Semantic proximity Read ↗

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