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Article

GSTM1 and GSTP1 Polymorphisms Affect Outcome in Colorectal Adenocarcinoma.

Medicina (Kaunas, Lithuania) - 28 Mar 2024

Stojkovic Lalosevic Milica, Coric Vesna, Pekmezovic Tatjana, Simic Tatjana, Pavlovic Markovic Aleksandra, Pljesa Ercegovac Marija

Abstract excerpt

Background and Objectives: Despite improvements in screening programs, a large number of patients with colorectal cancer (CRC) are diagnosed in an advanced disease stage. Previous investigations imply that glutathione transferases (GSTs) might be associated with the development and progression of CRC. Moreover, the detoxification mechanism of oxaliplatin, which represents the first line of treatment for advanced...

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Identifiers

PMID: 38674199
DOI: 10.3390/medicina60040553
PMCID: PMC11052438

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