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Article

Genetic polymorphisms in GST genes and survival of colorectal cancer patients treated with chemotherapy.

Pharmacogenomics - 1 Jan 2010

Funke Silvia, Timofeeva Maria, Risch Angela, Hoffmeister Michael, Stegmaier Christa, Seiler Christoph M, Brenner Hermann, Chang-Claude Jenny

Abstract excerpt

UNLABELLED: Glutathione S-transferases (GSTs) participate in the detoxification of chemotherapeutic agents. Genetic polymorphisms in GST genes (GSTP1 Ile105Val, copy-number variants of GSTM1 and GSTT1) that lead to diminished enzyme activity have been associated with increased chemotherapeutic treatment benefit in colorectal cancer patients. AIMS: We assessed the effect of genetic polymorphisms in GST genes on...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 20017670
DOI: 10.2217/pgs.09.132

Genes

GSTM1
GSTT1
GSTP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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